Impact of C1q fixing donor‐specific antibodies on renal transplant outcome
نویسندگان
چکیده
Abstract Not all anti‐HLA donor‐specific antibodies (HLA‐DSAs) are detrimental to renal allograft. In this context, the C1q complement activating ability of appears be an important parameter distinguish clinically inert versus DSAs. We evaluated sera 206 consecutive primary live donor transplant recipients before and at post‐operative day 7, 30, 90, 180 time graft dysfunction for quantifying HLA‐DSAs using single antigen bead assay on a Luminex platform. Patients positive these with MFI >500 were further screened fixing nature DSA. Fourteen 18 antibody‐positive patients had DSA value >5000. Only 4 did not have The values detected by generally higher least 25% than those conventional IgG‐SAB assay. Twelve 14 (85.71%) C1q+ developed antibody‐mediated rejection during mean follow‐up period 21.43 ± 8.03 months as compared none four C1q‐negative (85.71% vs 0%; P = .001). These results suggest deleterious effect vis‐à‐vis
منابع مشابه
Significance of C1q-fixing donor-specific antibodies after kidney transplantation.
OBJECTIVES De novo donor-specific HLA antibodies (DSA) are associated with allograft rejection and allograft loss. However, not all DSA are equally detrimental to allograft function. The ability to activate complement may be an important factor differentiating clinically relevant DSA from nonrelevant DSA. The C1q assay detects a subset of HLA antibodies that can fix complement. This study aimed...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2021
ISSN: ['0300-9475', '1365-3083']
DOI: https://doi.org/10.1111/sji.13048